Education：
1979 M.D. Medicine Kyoto Prefectural University of Medicine
1985 Ph.D. Physiology Kyoto Prefectural University of Medicine Professi2018 - present The Representative Director,
Kyoto Industrial Health Association
2018 - present The Vice President,
Kyoto Industrial Health Association
2018 - present The Director,
Clinic, Kyoto Industrial Health Association
2018 – present The Director,
Research Institute for Clinical Physiology,
Kyoto Industrial Health Association
2018 – present Professor,
Research Center for Drug Discovery and Pharmaceutical Development Science,
Research Organization of Science and Technology, Ritsumeikan University
2016 - present The President,
The Physiological Society of Japan
2015 - 2017 Director
Center for Information and Multimedia Studies
Kyoto Prefectural University of Medicine
2013 - 2018 Professor and Chairman
Department of Bio-Ionomics
Graduate School of Medical Science
Kyoto Prefectural University of Medicine
2013 - present Adjunct Professor
Department of Respiratory Medicine
Fudan University
Shanghai Respiratory Research Institute
2011 - present Professor and Director
Japan Institute for Food Education and Health
St. Agnes’ University
2007 - 2017 Director
Center for Medical Education and Research
Kyoto Prefectural University of Medicine
2003 - 2018 Professor and Chairman
Department of Molecular Cell Physiology
Graduate School of Medical Science
Kyoto Prefectural University of Medicine
2003 - 2010 Professor and Chairman
Department of Respiratory Medicine
Graduate School of Medical Science
Kyoto Prefectural University of Medicine
2003 - 2007 Professor and Chairman
Department of Biochemistry and Molecular Genetics
Research Institute for Neurological Diseases & Geriatrics
Kyoto Prefectural University of Medicine
2000 - 2003 Professor and Chairman
Department of Cellular and Molecular Physiology
School of Medicine
Kyoto Prefectural University of Medicine 1992 - 2000 Associate Professor
Institute of Medical Science
The University of Toronto
1992 - 2000 Associate Professor
Division of Respiratory Medicine
Department of Pediatrics
The University of Toronto Faculty of Medicine
1991 - 1992 Assistant Professor
Division of Respiratory Research
(Lung Biology Programme)
Research Institute
The Hospital for Sick Children
The University of Toronto
1988 - 1990 Assistant Professor of Physiology
Emory University School of Medicine
1986 – 1988 Associate
Department of Physiology
Emory University School of Medicine
1986 - 1986 Research Associate
Department of Physiology and Biophysics
University of Texas Medical Branch at Galveston
1985 - 1986 Instructor
Department of Physiology
Shiga University of Medical Scienceonal Experience： Scientific Research Field： 1. Food nutrition and health evaluation
2. Ion epithelial transmission control mechanism caused by hormone and osmotic pressure
3. Cancer cell growth control mechanism
4. Neural regeneration mechanism
5. Biological activity of chloride ions Social academic post and honor： The Premier's Research Excellence Award (1999)
The Government of Ontario
Marco Polo della Scienza Italiana (2013)
Italian Government Teaching Courses： Medical Physiology
Membrane Transport Published papers： Has published more than two hundred papers. The representative researches can be listed as follows:
1. Puppulin P, Hosogi S, Sun H, Matsuo K, Inui T, Kumamoto Y, Suzaki T, Tanaka H, MARUNAKA Y
Bioconjugation strategy for cell surface labelling with gold nanostructures designed for highly localized pH measurement
Nature Communications 9(1) 5278, 2018
2. MARUNAKA Y, Niisato N, Taruno A, Ohta M, Miyazaki M, Hosogi S, Nakajima K, Kusuzaki K, Ashihara E, Nishio K, Iwasaki Y, Nakahari T, Kubota T.
Regulation of epithelial sodium transport via epithelial Na+ channel (ENaC)
J Biomed Biotechnol 2011:978196, 2011
3. MARUNAKA Y, Yoshimoto K, Aoi W, Hosogi S, Ikegaya H
Low pH of interstitial fluid around hippocampus of the brain in diabetic OLETF rats
Molecular and Cellular Therapies 2:6, 2014
4. MARUNAKA Y
Roles of ionic environments in growth of human cancer cell and potentials of ion transporter blockers in cancer therapies
J Gastrointestinal and Digestive System 3:163, 2014
5. MARUNAKA Y
Importance of expression and function of angiotensin II receptor type 1 in pulmonary epithelial cells
Respiratory Physiol Neurobiol 196:39-42, 2014
6. MARUNAKA Y
Characteristics and pharmacological regulation of epithelial Na+ channel (ENaC) and epithelial Na+ transport
J Pharmacol Sci 126:21-36, 2014
7. MARUNAKA Y
Roles of interstitial fluid pH in diabetes mellitus: Glycolysis and mitochondrial function
World J Diabetes 6:125-135, 2015
8. MARUNAKA Y, Niisato N, Miyazaki H, Nakajima K, Taruno A, Sun H, Marunaka R, Okui M, Yamamoto T, Kanamura N, Kogiso H, Ikeuchi Y, Kashio M, Hosogi S, Nakahari T
Quercetin is a useful medicinal compound showing various actions including control of blood pressure, neurite elongation and epithelial ion transport
Current Med Chem 23:1-12, 2016
9. MARUNAKA Y, Marunaka R, Sun H, Yamamoto T, Kanamura N, Taruno A
Na+ homeostasis by epithelial Na+ channel (ENaC) and Nax channel (Nax): cooperation of ENaC and Nax
Annals of Translational Medicine 4 (Suppl 1):S11, 2016.
10. MARUNAKA Y, Marunaka R, Sun H, Yamamoto T, Kanamura N, Inui T, Taruno A.
Actions of quercetin, a polyphenol, on blood pressure.
Molecules 22(2). pii: E209, 2017.
11. MARUNAKA Y
Actions of quercetin, a flavonoid, on ion transporters: its physiological roles
Annals of the New York Academy of Sciences 1398(1):142-151, 2017
12. MARUNAKA Y.
The mechanistic links between insulin and cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel
Int J Mol Sci 18(8): pii: E1767, 2017
13. MARUNAKA Y
The proposal of molecular mechanisms of weak organic acids intake-induced improvement of insulin resistance in diabetes mellitus via elevation of interstitial fluid pH
Int J Mol Sci 19(10):3244, 2018 Main Scientific Research Projects： Four-University Collaborative Research Grant
Development of new system for drug delivery specific to cancer cells (2012 - 2013)
¥1,150,000
Japan Society of The Promotion of Science
Clarification of tumor metastatic mechanism caused by disturbance of WNK kinase-dependent Cl- transporter (2013-2016)
¥5,200,000
Japan Society of The Promotion of Science
Continuous pH measurement of interstitial fluid and clarification of pathogenic mechanism of insulin resistance by ISFET pH sensor (2013-2015)
¥3,770,000
KIT-KPUM-KPU-KPhU Collaborative Research Grant
Molecular cell mechanisms of interstitial pH-mediated appearance of insulin resistance in diabetes mellitus (2013 - 2014)
¥2,000,000
Yamada Research Grant
The prevention of Alzheimer’s disease and its complications through the improvement of interstitial pH by propolis intake (2013 - 2014)
¥4,900,000
Japan Society of The Promotion of Science
New targeting mechanisms of plasma proteins to proteasome (2015-2018)
¥4,940,000
Japan Society of The Promotion of Science
Development of non-invasive methods measuring interstitial fluid pH and HCO3- concentration by MRI and Raman (2015-2017)
¥3,770,000
Kyoto-Funding for Innovation in Health-related R&D Fields
Development of apparatus measuring interstitial fluid pH as a biomarker for early diagnosis of type 2 diabetes and Alzheimer's dementia (2015-2016)
¥1,300,000
KIT-KPUM-KPU-KPhU Collaborative Research Grant
Roles of interstitial fluid pH in development for type 2 diabetes and the Alzheimer's dementia and molecular mechanisms of regulation of interstitial fluid (2015 - 2016)
¥2,000,000
Japan Society of The Promotion of Science
Prevention of diabetes mellitus and Alzheimer dementia via improvement of low interstitial fluid pH by food constituent (2018-2021)
¥17,420,000 Patents： Medical light irradiation device JP 5702529 B2 2015.4.15 Scientific Research Achievements and Awards： Research Fellowship Abroad (1986 - 1988)
Ministry of Education, Science and Culture of Japan
Research Award (1989)
The National Kidney Foundation of U.S.A.
Scholarship (1991 - 1996)
Medical Research Council of Canada
Research Scholarship (1991 - 1996)
Heart and Stroke Foundation of Ontario Number of postgraduates under supervision： 44 Number of supervised masters and Ph.D. 52 Number of supervised undergraduates 154 The above information updated Sep.2021 |
